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FLASH GENE
Symbol CLCN2 contributors: mct/npt - updated : 18-12-2016
HGNC name chloride channel 2
HGNC id 2020
ANIMAL & CELL MODELS
  • ClCN2 deficient mice suffer from degeneration of male germ cells in testis and photoreceptors in the retina (Hohberger 2009)
  • white matter of the brain and spinal cord of ClC-2 knock-out mice developed widespread vacuolation that progressed with age (Blanz 2007)
  • increase in the amiloride-sensitive short-circuit current in Clcn2(-/-) mice revealed a compensatory mechanism that is activated in the colons of mice that lack the ClC-2 channel