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| Mice carrying the missense mutation (P23H) in the rhodopsin gene and mice overexpressing the wild-type human rodhopsin gene develop photoreceptor degeneration  | |
mice carrying a targeted disruption of the rhodopsin gene do not elaborate rod outer segments, there is no rod ERG response in 8-week-old animals and lose their photoreceptors over 3 months. Rho+/- mice display structural disorganization of the retina |
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rhodopsin knockout mice display completely photoreceptor cells degeneration |
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Rho-/- mice do not express the apoprotein opsin in photoreceptors are completely protected against light-induced apoptosis |
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English Mastiff dogs with a naturally occurring dominant retinal degeneration and a dramatically slowed time course of recovery of rod photoreceptor function after light exposure have a point mutation in the RHO gene (Thr4Arg) |
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rats expressing mutations in rhodopsin gene display photoreceptor cell damage from exposure to light |
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T17M mutant human rhodopsin transgene in mice exhibit a sensitivity to light-induced damage causing severe loss of a- and b-wave ERG responses and photoreceptor apoptosis |
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introduction of Rh1P37H mutation corresponding to human RhoP23H in Drosophila leads to photoreceptor degeneration due to rhodopsin mislocalizion |
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ENU-mutagenized mouse line (R3) carrying an homozygous Rho mutation (p.C185R) lose photoreceptors rapidly with flat a- and b-waves ERG, R3/+ mice have a slower rate of photoreceptor cell loss |