Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MCM9 contributors: npt/mct/pgu - updated : 12-04-2021
HGNC name minichromosome maintenance complex component 9
HGNC id 21484
ANIMAL & CELL MODELS
  • Mcm9 deficiency mouse have defect in spermatogonial self-renewal during adulthood, and distinct sex-specific cancers
  • MCM9(-/-) testes produce spermatozoa, albeit in much reduced quantity
  • Mcm9-deficient mice have gonadal failure, and fibroblasts from these mice show hypersensitivity to agents that induce DSBs and DNA crosslinks (i.e., ionizing radiation and MMC), resulting in a higher number of broken chromosomes, a hallmark of genomic instability