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FLASH GENE
Symbol NFE2L2 contributors: mct/npt/pgu/shn - updated : 02-07-2016
HGNC name nuclear factor (erythroid-derived 2)-like 2
HGNC id 7782
ANIMAL & CELL MODELS
  • Nrf2(-/-) mice were highly susceptible to N-acetyl-p-aminophenol treatment and died of liver failure
  • mice targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia due to increased sequestration of damaged erythrocytes .
  • Nrf2-deficient mice show decolourization of the incisors
  • Disruption of the Nrf2 gene in mice led to earlier-onset and more extensive cigarette smoke-induced emphysema
  • Disruption of Nrf2 dramatically increased the mortality of mice in response to endotoxin- and cecal ligation and puncture-induced septic shock
  • Nrf2-deficient mice developed tumors more readily in response to carcinogen exposure and caloric exposure was ineffective in suppressing tumors in the KO mice
  • expression levels of NRF1 is significantly decreased in both Alzheimer's disease hippocampal tissues and AD-causing amyloid precursor protein mutant cells
  • Nrf2-null mice develop diffuse white matter injury without overt loss of neurons