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FLASH GENE
Symbol TUB contributors: mct - updated : 14-09-2021
HGNC name tubby homolog (mouse)
HGNC id 12406
ANIMAL & CELL MODELS
  • Deletion mutation of the 44 AAs at tubby C-terminal end (Tubby-deltaC44) causes adult-onset obesity, retinal and cochlear degeneration in Tubby mice with unknown pathological mechanisms
  • a splicing defect-causing mutation in the 3'-end of the tubby gene, which is predicted to disrupt the carboxy-terminal region of the Tub protein, causes maturity-onset obesity, blindness, and deafness in mice