| RDH10(trex) mutant protein lacks the ability to oxidize retinol to retinal, resulting in insufficient RA signaling | |
severity of the Rdh10 null phenotype demonstrates that embryonic oxidation of retinol is carried out primarily by Rdh10 and that neither ADHs nor other enzymes contribute significantly to this reaction |
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deficiency of Rdh10 in both Sertoli and germ cells in juvenile mice results in a blockage of spermatogonial differentiation, similar to that seen in vitamin A-deficient animals |
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adult Rdh10-deficient mice exhibit phenotypically normal spermatogenesis, indicating that during development a change occurs in either the cellular source of RA or the retinaldehyde dehydrogenase involved in RA synthesis |