| mouse embryonic stem (ES) cells lacking c-Jun are viable and have a normal in vitro differentiation capacity | |
primary Jun-/- fibroblasts have a severe proliferation defect and undergo premature senescence in vitro |
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mouse primary JunAA (serines 63 and 73 mutated to alanines) fibroblasts have proliferation- and stress-induced apoptotic defects, accompanied by reduced AP-1 activity, and JunAA mice are viable and fertile, smaller than controls and resistant to epileptic seizures and neuronal apoptosis induced by the excitatory amino acid kainate |
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mouse primary hepatocytes lacking c-Jun showed increased sensitivity to TNF-alpha-induced apoptosis |
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embryos lacking c-Jun die at mid- to late-gestation and exhibit impaired hepatogenesis, altered fetal liver erythropoiesis and generalized oedema |
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Absence of mouse neuronal Jun reduced the speed of axonal regeneration following crush, and prevented most cut axons from reconnecting to their target, significantly reducing functional recovery ( |