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HGNC UniGene Nucleotide OMIM UCSC
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Symbol IGF1 contributors: mct/npt/pgu/shn - updated : 19-07-2013
HGNC name insulin-like growth factor 1 (somatomedin C)
HGNC id 5464
  • Newborn mice with IgfI null mutation exhibit a growth deficiency die shortly after birt or can each adulthood (
  • mice with severe IGF-1 deficiency display elevated blood pressure and enhanced myocardial contractility (
  • profound embryonic and postnatal growth retardation in IGF1 knockout mice
  • normoglycemic/normoinsulinemic transgenic mice overexpressing IGF-1 in the retina developed most alterations observed in human diabetic eye disease (
  • mice lacking both Insr and Ifg1r developed diabetes in contrast to mild phenotypes observed in single mutants
  • IGF1 knockout mice have defects in neurologic development
  • IGF1 decreased photoreceptor apoptosis in rd1 mouse retinal explants in parallel with reduced activation of calpain-2 and increased levels of calpastatin and activation of phospho-CREB (