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FLASH GENE
Symbol TBX2 contributors: mct/pgu - updated : 29-08-2016
HGNC name T-box 2
HGNC id 11597
ANIMAL & CELL MODELS
  • Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression
  • lungs of Tbx2-deficient mice are markedly hypoplastic and exhibit reduced branching morphogenesis