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FLASH GENE
Symbol RORA contributors: mct/ - updated : 06-06-2018
HGNC name RAR-related orphan receptor A
HGNC id 10258
ANIMAL & CELL MODELS
  • (sg/sg) mouse,with a staggerer mutation consisting of an intragenic CNV that results in a 122-bp frameshifting deletion that truncates the ligand binding domain, leading to the loss of Rora activity (this phenotype is similar to Rora-/- mice)
  • liver-specific Rora-deficient mice develop hepatic steatosis, obesity and insulin resistance when challenged with a high-fat diet (HFD)
  • mice lacking a functional ROR&
  • 945; display a range of metabolic abnormalities including decreased serum cholesterol and plasma triglycerides