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FLASH GENE
Symbol APOE contributors: mct/pgu - updated : 17-05-2017
HGNC name apolipoprotein E
HGNC id 613
ANIMAL & CELL MODELS
  • apoE4 causes age- and Tau-dependent impairment of hilar GABAergic interneurons, leading to learning and memory deficits in mice (
  • young Apoe4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex
  • hyper-neovascularization in the apoE4 mice might be driven by increased inflammation and the associated surge in Vegfa following injury
  • APOE4 reduces evoked hippocampal acetylcholine release in adult mice