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Symbol KLC1 contributors: shn/npt - updated : 03-10-2017
HGNC name kinesin light chain 1
HGNC id 6387
  • KLC1 gene-targeted mice results in significantly smaller mutant mice that also exhibited pronounced motor disabilities (
  • in living mice carrying a deletion of the kinesin light chain 1 (KLC1&
  • 8722;/&
    8722;) motor subunit revealed delayed axonal transport rates, and t early and selective transport defects can activate c-Jun N-terminal stress kinase (JNK) pathways that initiate abnormal hyperphosphorylation of tau in the absence of Abeta toxicity (
  • mislocalization of opsin is a major cause of photoreceptor cell death from kinesin-2 dysfunction (