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| KLC1 gene-targeted mice results in significantly smaller mutant mice that also exhibited pronounced motor disabilities ( | |
in living mice carrying a deletion of the kinesin light chain 1 (KLC1& |
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8722;/& |
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8722;) motor subunit revealed delayed axonal transport rates, and t early and selective transport defects can activate c-Jun N-terminal stress kinase (JNK) pathways that initiate abnormal hyperphosphorylation of tau in the absence of Abeta toxicity ( |
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mislocalization of opsin is a major cause of photoreceptor cell death from kinesin-2 dysfunction ( |