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FLASH GENE
Symbol SIRT6 contributors: mct/pgu/shn - updated : 21-01-2015
HGNC name sirtuin 6
HGNC id 14934
ANIMAL & CELL MODELS
  • mice deficient for SIRT6 are small and at 2-3 weeks of age develop abnormalities that include profound lymphopenia, loss of subcutaneous fat, lordokyphosis, and severe metabolic defects, eventually dying at about 4 weeks and exhibit genome instability (
  • SIRT6-deficient mice develop normally but succumb to a lethal hypoglycemia early in life (
  • SIRT6-deficient cells exhibit increased Hif1alpha activity and show increased glucose uptake with upregulation of glycolysis and diminished mitochondrial respiration (
  • Abrogation of these SIRT6 activities leads to impaired resolution of DNA double-strand break (
  • liver-specific deletion of SIRT6 in mice causes profound alterations in gene expression, leading to increased glycolysis, triglyceride synthesis, reduced beta oxidation, and fatty liver formation
  • mice overexpressing Sirt6 are protected against diet-induced obesity
  • SIRT6(-/-) animals had very low levels of blood glucose and died shortly after weaning
  • SIRT6-deficient mice have a striking degenerative phenotype leading to shortened lifespan and are associated with hypoglycemia and defects in DNA repair