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Symbol TRPV4 contributors: mct/ - updated : 09-10-2017
HGNC name transient receptor potential cation channel, subfamily V, member 4
HGNC id 18083
  • TRPV4-deficient mice displayed impairment of the intercellular junction-dependent barrier function in the skin
  • chondrocytes from Trpv4-null mice do not respond to hypo-osmotic stress suggesting that the mechanosensory role of TRPV4 is important in articular cartilage
  • pharmacological inhibition of Trpv4 in mice modulate both thermogenic and proinflammatory pathways in fat, resulting in a robust resistance to obesity and insulin resistance