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FLASH GENE

Symbol

TRPV1

contributors: shn/npt/pgu - updated : 27-02-2016

HGNC name	transient receptor potential cation channel, subfamily V, member 1
HGNC id	12716

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Vr1-/- mice were viable, fertile, and largely indistinguishable from wildtype littermates but sensory neurons from these mice are severely deficient in their responses to vanilloid compounds, protons, or heat greater than 43 degrees C
	Trpv1-null mice had more frequent low-amplitude bladder activity than normal mice
	Trpv1-/- mice had enhanced insulin sensitivity
	mice lacking Trpv1 pain receptors are long-lived, displaying a youthful metabolic profile at old age