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FLASH GENE
Symbol TRPV1 contributors: shn/npt/pgu - updated : 27-02-2016
HGNC name transient receptor potential cation channel, subfamily V, member 1
HGNC id 12716
ANIMAL & CELL MODELS
  • Vr1-/- mice were viable, fertile, and largely indistinguishable from wildtype littermates but sensory neurons from these mice are severely deficient in their responses to vanilloid compounds, protons, or heat greater than 43 degrees C
  • Trpv1-null mice had more frequent low-amplitude bladder activity than normal mice
  • Trpv1-/- mice had enhanced insulin sensitivity
  • mice lacking Trpv1 pain receptors are long-lived, displaying a youthful metabolic profile at old age