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FLASH GENE
Symbol SORT1 contributors: shn/ - updated : 11-10-2017
HGNC name sortilin 1
HGNC id 11186
ANIMAL & CELL MODELS
  • SORT1-knockout mice have reduced levels of neuronal apoptosis in the developing retina, are protected against agedependent degeneration of sympathetic neurons and are
  • rescued from axotomy-induced death of corticospinal motor neurons
  • overexpression in mouse liver, we demonstrate that Sort1 alters plasma LDL-C and very low-density lipoprotein (VLDL) particle levels by modulating hepatic VLDL secretion