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FLASH GENE
Symbol NGFR contributors: mct/shn/ - updated : 11-10-2015
HGNC name nerve growth factor receptor
HGNC id 7809
ANIMAL & CELL MODELS
  • mice with NGF receptor p75 mutation are viable and fertile display markedly decreased sensory innervation, loss of heat sensitivity associated with ulcers in the distal extremities
  • light-induced photoreceptor apoptosis in p75NTR knockout mice is significantly reduced
  • impairment of hippocampal long-term potentiation in p75NTR-deficient mouse
  • mice depleted for p75NTR exacerbate liver pathology and inhibited hepatocyte proliferation in vivo