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Symbol MAPT contributors: mct/pgu - updated : 26-01-2017
HGNC name microtubule-associated protein tau
HGNC id 6893
  • mice overexpress the 4R human tau isoform develop axonal degeneration in brain and spinal cord
  • mice expressing mutant (P301L) tau protein exhibit neurofibrillary tangles amyotrophy and progressive motor disturbance
  • double mutant (tau/APP (beta-amyloid precursor protein)) mice develop Abeta deposits and exhibit neurofibrillary tangle pathology enhanced in the limbic system and olfactory cortex
  • mice expressing a repressible human tau variant developed progressive age-related neurofibrillary tangles, neuronal loss, and behavioral impairments