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Symbol NPR1 contributors: mct/npt - updated : 26-03-2018
HGNC name natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
HGNC id 7943
ANIMAL & CELL MODELS
  • after 4 weeks of administering aldosterone and a high-salt diet, Gc-a knockout mice, but not wild-type mice, exhibited accelerated hypertension with massive proteinuria
  • disruption of Npr1 gene activates proinflammatory cytokines leading to fibrosis, hypertrophic growth, and remodeling of the kidneys of mutant mice