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FLASH GENE

Symbol

MYOZ2

contributors: shn/npt - updated : 18-03-2009

HGNC name	myozenin 2
HGNC id	1330

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Myoz2 -/- mice showed an enhanced calcineurin signaling in striated muscle, an excess of slow skeletal muscle fibers and an accelerated cardiomyopathy in response to pathological biomechanical stress
	Myoz2-overexpressing mice did not develop cardiac hypertrophy and had no impairment of contractile function by cardiac catheterization and echocardiography