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FLASH GENE
Symbol NLGN3 contributors: mct - updated : 02-07-2012
HGNC name neuroligin 3
HGNC id 14289
ANIMAL & CELL MODELS
  • in Nl3(R451C) mutant mice, a single point mutation in a synaptic cell adhesion molecule causes context-dependent changes in synaptic transmission, and these changes are consistent with the broad impact of this mutation on murine and human behaviors
  • NL-3-deficient mice display a behavioral phenotype reminiscent of the lead symptoms of ASD: reduced ultrasound vocalization and a lack of social novelty preference