Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ITCH contributors: mct/pgu - updated : 12-09-2016
HGNC name itchy E3 ubiquitin protein ligase homolog (mouse)
HGNC id 13890
ANIMAL & CELL MODELS
  • absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells
  • Itch(-/-) mice develop an autoimmune disease phenotype characterized by itchy skin and multiorgan inflammation
  • adult Itch(-/-) mice had normal bone volume, but they had significantly increased LPS-induced osteoclastogenesis and bone resorption