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FLASH GENE
Symbol NECTIN3 contributors: mct/shn/pgu - updated : 20-12-2016
HGNC name nectin cell adhesion molecule 3
HGNC id 17664
ANIMAL & CELL MODELS
  • Nectin-3(-/-) mice had defects in the later steps of sperm morphogenesis including distorted nuclei, abnormal distribution of mitochondria and in localization of nectin-2 at the Sertoli-spermatid junctions
  • Pvrl3 knockout mice as well as a spontaneous mouse mutant ari (anterior retinal inversion), that maps to the Pvrl3 locus, exhibit lens and other ocular defects involving the ciliary body
  • homozygous deletion of either Nectin2 or Nectin3 leads to male-specific infertility in mice