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FLASH GENE
Symbol NR1H3 contributors: mct - updated : 23-08-2016
HGNC name nuclear receptor subfamily 1, group H, member 3
HGNC id 7966
ANIMAL & CELL MODELS
  • Lxra -/- mice failed to induce transcription of the gene encoding cholesterol 7-alpha-hydroxylase. this defect was associated with a rapid accumulation of large amounts of cholesterol in the liver and the regulation of several other crucial lipid metabolizing genes was also altered(Peet, 98)
  • mice lacking Nr1h2, Nr1h3 manifested a breakdown in self-tolerance and developed autoantibodies and autoimmune glomerulonephritis