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FLASH GENE
Symbol FOXO1 contributors: mct - updated : 17-08-2020
HGNC name forkhead box O1
HGNC id 3819
ANIMAL & CELL MODELS
  • FoxO1-deficient embryos manifest progressive apoptotic cell death
  • mice lacking FOXO1 in steroidogenic factor 1 (NR5A1) neurons of the ventromedial hypothalamus are lean due to increased energy expenditure
  • mice with Treg-cell-specific deletion of Foxo1 develop a fatal inflammatory disorder similar in severity to that seen in Foxp3-deficient mice, but without the loss of Treg cells