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FLASH GENE
Symbol VAV3 contributors: mct - updated : 23-05-2018
HGNC name vav guanine nucleotide exchange factor 3
HGNC id 12659
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in human prostate cancers
tumoral     --low  
highly methylated (85 p100 or more) in cancer cells (Gastric cancer)
Susceptibility
  • to hypertension, diabetes, obesity
  • to Paget disease of bone
  • Variant & Polymorphism other
  • carrier of the T allele in VAV3 rs7528153 polymorphism is associated with a decreased susceptibility of developing a pathologic state composed by the presence of hypertension, diabetes, obesity or cardiovascular damage, and with an increased risk of developing altered basal glycaemia
  • VAV3 rs7528153 polymorphism is a likely susceptibility factor for developing Paget disease of bone
  • Candidate gene
    Marker
  • VAV3 in peripheral blood may serve as a biomarker for gastric cancer, and to predict the lymphatic metastasis in gastric cancer
  • VAV3 overexpression could be a useful marker for predicting the outcomes of colorectal cancer (CRC) patients
  • Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneostéoporosis
    potential new target for antiosteoporosis therapy
    cancerdigestivecolon
    VAV3 targeting represents a potential modality for treating CRC
    cancerreproductiveprostate
    VAV3-CDC37 interaction may provide a new therapeutic target in prostate cancer
    ANIMAL & CELL MODELS
  • Vav3-deficient mice develop hypertension, tachycardia, and renocardiovascular dysfunctions
  • Vav3-deficient mice exhibit a transient delay in cerebellar development