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FLASH GENE
Symbol SLC2A9 contributors: mct/npt - updated : 14-12-2013
HGNC name solute carrier family 2 (facilitated glucose transporter), member 9
HGNC id 13446
ASSOCIATED DISORDERS
corresponding disease(s) RHU2
Susceptibility
  • to gout
  • to hyperuricemia
  • Variant & Polymorphism SNP , other
  • significant association between the SLC2A9 isoform 2 and urate concentrations and gout
  • genetic variants significantly associated with uric acid levels, association strongly modified by age and sex (Brandstätter 2009)
  • some of SNP in SLC2A9 may increase the risk of hyperuricemia
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    metabolismuric acid 
    can be a promising therapeutic target for hyperuricemia, gout, and related cardiovascular diseases
    ANIMAL & CELL MODELS
  • mice carrying a deletion of Glut9 in the whole body are hyperuricemic and display a severe nephropathy due to intratubular uric acid precipitation
  • Glut9-deficient mice develop impaired enterocyte uric acid transport kinetics, hyperuricaemia, hyperuricosuria, spontaneous hypertension, dyslipidaemia and elevated body fat