Symbol
| CYLD
| contributors: mct - updated : 08-07-2013
|
HGNC name
| cylindromatosis (turban tumor syndrome)
|
HGNC id
| 2584
|
corresponding disease(s)
|
CYLD
, MFT
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
|  
| loss of function
|
in pilotrichomas | tumoral
|  
|  
|  
| loss of function
|
enhances activation of the transcription factor NF-KB and leads to increased resistance to apoptosis and advanced carcinogenesis | tumoral
|  
| LOH
|  
|  
|
in multiple myeloma with poor prognosis | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
immunology | infectious | | |
transient inhibition of the activity of CYLD by pharmacological agents might provide a strategy to enhance antiviral responses |
| | | |
| upon high dose systemic listeriosis infection, all C57BL/6 Cyld(-/-) mice survived, whereas wildtype mice succumbed due to severe liver pathology with impaired pathogen control and hemorrhage within 6 days |