Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DNAJA1 contributors: mct - updated : 27-08-2019
HGNC name DnaJ (Hsp40) homolog, subfamily A, member 1
HGNC id 5229
ASSOCIATED DISORDERS
corresponding disease(s) IDSD
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in Colorectal cancer tissues and positively correlated with serosa invasion, lymph node metastasis
tumoral     --low  
in pancreatic cancer cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • targeted as a biomarker for pancreatic cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    farnesylated DNAJA1 is a crucial chaperone in maintaining mutant TP53 stabilization and targeting farnesylated DNAJA1 by atorvastatin will be critical for inhibiting TP53 mutant cancer
    immunologyinfectious 
    Targeting the interactions between polymerase subunits and DnaJA1 may provide a novel strategy to develop antiviral drugs
    ANIMAL & CELL MODELS
  • loss of DjA1 in mice led to severe defects in spermatogenesis that involve aberrant androgen signaling