Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ROCK1 contributors: mct/pgu - updated : 21-05-2016
HGNC name Rho-associated, coiled-coil containing protein kinase 1
HGNC id 10251
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
causes whole body insulin resistance by impairing insulin signaling in skeletal muscle, suggesting that activation of ROCK1 is essential for the normal actions of insulin on glucose transport in skeletal muscle
tumoral somatic mutation     gain of function
three somatic mutations leading to elevated kinase activity and driving actin cytoskeleton rearrangements that promote increased motility and decreased adhesion (characteristics of cancer progression)
tumoral     --over  
in various tumor cell lines and tumor tissues from osteosarcoma patients
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductivebreast
potential target in breast cancer
immunologyinflammatory 
may represent a promising therapeutic target in vascular inflammatory diseases
cancerbone 
may be a promising therapeutic target for the treatment of osteosarcoma patients.
neuromuscularspinal muscular atrophy 
therapeutic potential of ROCK1 inhibition in SMA
neurologyneurodegenerativehuntington chorea
A signaling pathway from ROCK1 to profilin thus controls polyglutamine protein aggregation and is targeted by a promising therapeutic lead for HD
ANIMAL & CELL MODELS
ROCK1-deficient mice exhibited insulin resistance, as revealed by the failure of blood glucose levels to decrease after insulin injection