Symbol
| RACK1
| contributors: mct/shn - updated : 17-05-2019
|
HGNC name
| receptor for activated C kinase 1
|
HGNC id
| 4399
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
|  
|  
|  
| gain of function
|
in the endothelium of tumor neovascularization | tumoral
|  
|  
| --over
|  
|
in patients with hepatocellular carcinoma | tumoral
|  
|  
| --over
|  
|
in Non-small-cell lung cancer (NSCLC) samples, and its expression correlated with tumor stage, metastasis, and degree of differentiation | tumoral
| fusion
|  
|  
|  
|
TRIM52-RACK1 in oral squamous cell carcinoma | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| serves as a potential biomarker of Non-small-cell lung cancer (NSCLC) | |
reliable molecular biomarker for the diagnosis of prostate carcinoma | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | lung | | |
serves as a therapeutic target of NSCLC | cancer | digestive | colon | |
inhibits growth and induces death of colon cells, suggesting novel colon cancer therapies that mimic GNB2L1 function |
| | |
| RACK1 overexpression resulted in reduced IGF-I-induced cell growth in both anchorage-dependent, anchorage-independent conditions enhanced cell spreading, increased stress fibers, increased focal adhesions accompanied by increased tyrosine phosphorylation of focal adhesion kinase and paxillin |