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FLASH GENE
Symbol GNB2L1 contributors: mct/shn - updated : 17-05-2012
HGNC name guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
HGNC id 4399
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
in the endothelium of tumor neovascularization
tumoral     --over  
in patients with hepatocellular carcinoma
tumoral     --over  
in Non-small-cell lung cancer (NSCLC) samples, and its expression correlated with tumor stage, metastasis, and degree of differentiation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • serves as a potential biomarker of Non-small-cell lung cancer (NSCLC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    serves as a therapeutic target of NSCLC
    cancerdigestivecolon
    inhibits growth and induces death of colon cells, suggesting novel colon cancer therapies that mimic GNB2L1 function
    ANIMAL & CELL MODELS
  • RACK1 overexpression resulted in reduced IGF-I-induced cell growth in both anchorage-dependent, anchorage-independent conditions enhanced cell spreading, increased stress fibers, increased focal adhesions accompanied by increased tyrosine phosphorylation of focal adhesion kinase and paxillin