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FLASH GENE

Symbol

GNB2L1

contributors: mct/shn - updated : 17-05-2011

HGNC name	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
HGNC id	4399

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in the endothelium of tumor neovascularization tumoral     --over   in patients with hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	inhibits growth and induces death of colon cells, suggesting novel colon cancer therapies that mimic GNB2L1 function

ANIMAL & CELL MODELS

RACK1 overexpression resulted in reduced IGF-I-induced cell growth in both anchorage-dependent, anchorage-independent conditions enhanced cell spreading, increased stress fibers, increased focal adhesions accompanied by increased tyrosine phosphorylation of focal adhesion kinase and paxillin