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FLASH GENE
Symbol MLXIPL contributors: mct/pgu - updated : 22-10-2016
HGNC name MLX interacting protein-like
HGNC id 12744
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
may exacerbate beta-cell dysfunction and accelerate beta-cell failure in type 2 diabetes
Susceptibility to reduced triglyceride level
Variant & Polymorphism SNP
  • G771C (Gln241His) associated with plasma triglyceride levels (lower triglyceride level)
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    strategies to reduce MXIPL activity might protect against beta-cell dysfunction in type 2 diabetes
    diabetemetabolic syndrom 
    may be a novel strategy for preventing and treating obesity-related metabolic dysfunction and type 2 diabetes
    ANIMAL & CELL MODELS
  • Mice deleted for both alleles of ChREBP display diminished rates of hepatic glycolysis and lipogenesis resulting in high liver glycogen content, low plasma free fatty acid levels and reduced adipose tissue mass