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FLASH GENE
Symbol EIF3H contributors: mct - updated : 05-03-2011
HGNC name eukaryotic translation initiation factor 3, subunit H
HGNC id 3273
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
breast and prostate cancer, hepatocellular carcinoma
tumoral   amplification    
with MYC, are frequently coamplified in non-small cell lung cancer and a high copy number correlates with increased epidermal growth factor receptor tyrosine kinase inhibitors sensitivity
Susceptibility to colorectal cancer(CRC)
Variant & Polymorphism SNP , other
  • increasing the risk of colorectal cancer
  • rs16888589 increases the expression of EIF3H and increased expression of this gene increases CRC growth
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS