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FLASH GENE
Symbol ATF1 contributors: shn/npt - updated : 10-07-2019
HGNC name activating transcription factor 1
HGNC id 783
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation    
involved in malignant melanoma or clear cell sarcoma of soft tissues with translocation t(12;22)(q13;q12) (see EWSR1)
tumoral        
Angiomatoid fibrous histiocytoma (AFH) due to EWSR1-ATF1 fusion genes
tumoral        
angiomatoid fibrous histiocytoma due to fusion of the FUS and ATF-1 genes
tumoral fusion      
with EWSR1 is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland
Susceptibility
  • to clear cell sarcoma of tendons and aponeuroses
  • to colorectal cancer
  • Variant & Polymorphism SNP
  • SNP rs11169571 and SNP rs11169552 are associated with risk of colorectal cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS