| homozygous disruption of the Rps6kb1 gene does not affect viability or fertility of mice, but that it has a significant effect on animal growth, especially during embryogenesis | |
S6K1(-/-) mice are significantly smaller and S6K1(-/-)/S6K2(-/-) mice show a sharp reduction in viability due to perinatal lethality |
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mice deficient for S6 Kinase 1 are hypoinsulinaemic, glucose intolerant and have reduced beta-cell mass but S6K1-deficient mice are protected against obesity owing to enhanced beta-oxidation |
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mice deleted for S6K1 have increased life span and are resistance to age-related pathologies |