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FLASH GENE
Symbol FANCF contributors: mct/npt - updated : 08-06-2021
HGNC name Fanconi anemia, complementation group F
HGNC id 3587
ASSOCIATED DISORDERS
corresponding disease(s) FANCF
related resource Fanconi Anaemia Mutation Database
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in advanced stage invasive cervical cancer and in acute myeloid leukemia by promoter hypermethylation
tumoral       loss of function
in leukemia
tumoral       loss of function
by methylation of the promoter in a subset of ovarian, oral, lung, and cervical cancers
Susceptibility
  • to acquired pure red cell aplasia
  • to epithelial ovarian cancer (EOC)
  • Variant & Polymorphism other
  • FANCF mutations may be associated with acquired PRCA
  • CpG island methylation of FANCF gene promoter region is strongly associated with the susceptibility and clinicopathologic features of EOC
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS