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FLASH GENE
Symbol TRPS1 contributors: mct - updated : 12-05-2017
HGNC name trichorhinophalangeal syndrome I
HGNC id 12340
ASSOCIATED DISORDERS
corresponding disease(s) TRPS1 , TRPS2 , TRPS3 , HTC1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in androgen-independent prostate cancer and in breast cancer
constitutional     --low  
stimulates epithelial-mesenchymal transition and metastasis through repression of FOXA1
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • mice with a disrupted Trps1 gene develop a chondrodysplasia characterized by diminished chondrocyte proliferation and decreased apoptosis in growth plates (Suemoto 2007)
  • lLoss of Trps1 in mice leads to an increased proportion of cells arrested in mitosis and, subsequently, to chromosome segregation defects
  • hair follicle development in Trps1 KO embryos is impaired directly or indirectly by decreased Noggin expression