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FLASH GENE
Symbol FCGR3A contributors: mct/npt - updated : 04-09-2017
HGNC name Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
HGNC id 3619
ASSOCIATED DISORDERS
corresponding disease(s) IMD20
Susceptibility
  • to systemic lupus erythematosus (SLE)
  • to viral infections, recurrent and neutropenia, alloimmune neonatal
  • to Takayasu arteritis
  • to HIV infection and progression
  • to immune thrombocytopenia (ITP)
  • Variant & Polymorphism other
  • genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus
  • homozygous for the high activity allele of FCGR3A (158VV) were predominantly found among HIV progressors and this group was also skewed toward higher allele frequencies for the V158 variant
  • FCGR3A (158V/F) polymorphism, known to increase the affinity of FCGR3A to IgG, was over-represented in ITP patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS