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FLASH GENE
Symbol TPT1 contributors: mct/npt/pgu - updated : 23-03-2010
HGNC name tumor protein, translationally-controlled 1
HGNC id 12022
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in gastric cancer
tumoral     --over  
in many cancers
constitutional     --low  
may result in sequestration of active cofilin by a monomeric pool of actin
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
for fortilin-overexpressing cancers
cancer  
is a "stress hallmark" that may be exploited as a therapeutic target to decrease the resistance of cancer cells to anticancer therapy
ANIMAL & CELL MODELS