Symbol
| CD52
| contributors: mct - updated : 13-07-2022
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HGNC name
| CD52 molecule
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HGNC id
| 1804
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Other morbid association(s)
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Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
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constitutional
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| --over
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by B cells in Systemic lupus erythematosus (SLE) represents a homeostatic mechanism to suppress B cell hyperactivity | constitutional
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| --over
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in mature adipocytes and preadipocytes | |
Variant & Polymorphism
| CD52 polymorphism may affect the efficiency of GPI-anchor formation and thus may indirectly alter the response to anti-CD52 agents in renal transplants recipient (Oko 2009) |
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Candidate gene
Marker
| CD52 is a novel marker in neoplastic mast cells (MCs) in patients with advanced systemic mastocytosis (SM) | Therapy target
| |
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System | Type | Disorder | Pubmed |
diabete | type 2 | | |
may functioned as an important potential target for obesity with T2DM via TGF-β/Smad3 axis | cancer | hemopathy | | |
potential therapeutic target in Waldenstrom's macroglobulinemia and mast cell disorders | cancer | hemopathy | | |
potential therapeutic target in neoplastic mast cells (MCs) in patients with advanced systemic mastocytosis (SM) |
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