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FLASH GENE
Symbol CD52 contributors: mct - updated : 13-07-2022
HGNC name CD52 molecule
HGNC id 1804
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
by B cells in Systemic lupus erythematosus (SLE) represents a homeostatic mechanism to suppress B cell hyperactivity
constitutional     --over  
in mature adipocytes and preadipocytes
Susceptibility
Variant & Polymorphism
  • CD52 polymorphism may affect the efficiency of GPI-anchor formation and thus may indirectly alter the response to anti-CD52 agents in renal transplants recipient (Oko 2009)
  • Candidate gene
    Marker
  • CD52 is a novel marker in neoplastic mast cells (MCs) in patients with advanced systemic mastocytosis (SM)
  • Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    may functioned as an important potential target for obesity with T2DM via TGF-β/Smad3 axis
    cancerhemopathy 
    potential therapeutic target in Waldenstrom's macroglobulinemia and mast cell disorders
    cancerhemopathy 
    potential therapeutic target in neoplastic mast cells (MCs) in patients with advanced systemic mastocytosis (SM)
    ANIMAL & CELL MODELS