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FLASH GENE
Symbol FOXD3 contributors: mct - updated : 28-04-2015
HGNC name forkhead box D3
HGNC id 3804
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
results in developmental failure of melanoblasts and vitiligo
Susceptibility to vitiligo
Variant & Polymorphism SNP -639G>T promoter substitution may be the cause of AIS1-dependent vitiligo
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • mice carrying a pancreas-specific deletion of Foxd3 have impaired glucose tolerance, decreased beta-cell mass, decreased bet-cell proliferation, and decreased beta-cell size during pregnancy