Symbol
| FOXD3
| contributors: mct - updated : 28-04-2015
|
HGNC name
| forkhead box D3
|
HGNC id
| 3804
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
results in developmental failure of melanoblasts and vitiligo | |
Susceptibility
|
to vitiligo |
Variant & Polymorphism
SNP
| -639G>T promoter substitution may be the cause of AIS1-dependent vitiligo |
|
|
Candidate gene
Marker
Therapy target
| | | |
| mice carrying a pancreas-specific deletion of Foxd3 have impaired glucose tolerance, decreased beta-cell mass, decreased bet-cell proliferation, and decreased beta-cell size during pregnancy |