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FLASH GENE
Symbol GADD45G contributors: mct - updated : 03-04-2019
HGNC name growth arrest and DNA-damage-inducible, gamma
HGNC id 4097
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
of GADD45G-ZEB2 axis may contribute to cellular senescence evasion and hepatocellular carcinoma (HCC) development
Susceptibility
Variant & Polymorphism
Candidate gene
  • is a candidate gene for male infertility and 46,XY sex reversal in humans
  • Marker
  • GADD45G suppression is a poor prognostic factor in patients with hepatocellular carcinoma (HCC)
  • Therapy target
    ANIMAL & CELL MODELS
  • Gadd45g(-/-) XY mice were born as completely sex-reversed XY-females, whereas lack of Gadd45a and/or Gadd45b did not affect primary sex determination or testis development