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Symbol NDRG2 contributors: mct/npt/pgu - updated : 21-09-2015
HGNC name NDRG family member 2
HGNC id 14460
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
by hypermethylation of the promoter in grade III meningioma
tumoral     --low  
in liver and pancreatic cancers
tumoral     --low  
in glioblastoma, lung and breast cancer, and clinically aggressive meningioma
constitutional     --over  
in Alzheimer disease
tumoral     --over  
overexpression inhibits glioblastoma (GBM) cell proliferation, and decreased NDRG2 expression correlates with decreased GBM patient survival
tumoral     --low  
dependent on promoter methylation, was seen in the majority of oral squamous-cell carcinoma cases and in several cases of precancerous leukoplakia with dysplasia
tumoral     --low  
in colorectal cancer compared to benign colorectal tissues, and hypermethylation of NDRG2 was significantly correlated with nodal metastasis and poor differentiation
Variant & Polymorphism
Candidate gene
  • biomarker to predict aggressive behavior in patients with meningioma
  • aberrant hypermethylation of the NDRG2 gene could be a molecular marker for detection and treatment of human colorectal cancers
  • Marker
    Therapy target
    cancerhead and neck 
    potential target for therapeutic intervention in oral squamous-cell carcinoma
    Tbx2 in the embryonic mouse heart at early stages of development throughout the myocardium of the heart tube both represses proliferation and impairs secondary heart field (SHF) progenitor cell deployment into the outflow tract (OFT), implicating the upregulation of Ndrg2 and downregulation of Ndrg4 expression