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FLASH GENE
Symbol SULF2 contributors: mct/npt - updated : 30-05-2017
HGNC name sulfatase 2
HGNC id 20392
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
proangiogenic heparan sulfate endosulfatase, upregulated in breast cancer (Morimoto-Tomita 2005)
tumoral     --over  
in most lung tumours showing differential cellular distribution of full length and shorter SULF2 variants in such tumours
tumoral     --over  
in pancreatic ductal adenocarcinoma was associated with advanced tumour stage, vascular invasion, shorter interval to radiological progression and shorter overall survival
constitutional     --over  
in cirrhotic liver compared to healthy liver
constitutional     --over  
in idiopathic pulmonary fibrosis (IPF)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • SULF2 methylation is a common abnormality and a prognostic biomarker for better survival of lung cancer patients
  • may be a useful serologic biomarker for liver cirrhosis
  • may have roles as a prognostic biomarker in pancreatic ductal adenocarcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    therapeutic target for patients with PDAC
    ANIMAL & CELL MODELS