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FLASH GENE
Symbol KIF5B contributors: mct/npt - updated : 14-10-2014
HGNC name kinesin family member 5B
HGNC id 6324
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
KIF5B-RET fusion promotes the cell growth and tumorigenicity of non-small cell lung cancers through multilevel activation of STAT3 signaling
constitutional     --low  
in diabetes high glucose decreased KIF5B, SNAP25 and synaptophysin immunoreactivity specifically in axons of hippocampal neurons which may lead to changes in synaptic proteins, thus contributing to changes in hippocampal neurotransmission and to cognitive and memory impairments
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS