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FLASH GENE

Symbol

MSLN

contributors: shn/npt - updated : 09-02-2013

HGNC name	mesothelin
HGNC id	7371

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   only in ovarian carcinoma and mesotheliomas tumoral     --over   promotes breast cancer cell invasiveness and metastasis tumoral     --over   by hypomethylation in malignant mesothelioma tumoral     --over   in human pancreatic cancer, leading to constitutive activation of STAT3, which results in enhanced expression of cyclin E and cyclin E/cyclin-dependent kinase 2 complex formation as well as increased G(1)-S transition

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	useful biomarker for breast cancer progression
Therapy target
	System Type Disorder Pubmed cancer     potential new therapeutic agent for preventing or treating peritoneal malignant tumors cancer reproductive breast novel therapeutic or chemopreventive target in human breast cancer

ANIMAL & CELL MODELS

mice disrupted for msln gen were viable, fertile and anatomically normal