Symbol
| MSLN
| contributors: shn/npt - updated : 09-02-2013
|
HGNC name
| mesothelin
|
HGNC id
| 7371
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --other
|  
|
only in ovarian carcinoma and mesotheliomas | tumoral
|  
|  
| --over
|  
|
promotes breast cancer cell invasiveness and metastasis  | tumoral
|  
|  
| --over
|  
|
by hypomethylation in malignant mesothelioma  | tumoral
|  
|  
| --over
|  
|
in human pancreatic cancer, leading to constitutive activation of STAT3, which results in enhanced expression of cyclin E and cyclin E/cyclin-dependent kinase 2 complex formation as well as increased G(1)-S transition  | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| useful biomarker for breast cancer progression  | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | |  |
potential new therapeutic agent for preventing or treating peritoneal malignant tumors | cancer | reproductive | breast |  |
novel therapeutic or chemopreventive target in human breast cancer
|
| | |
| mice disrupted for msln gen were viable, fertile and anatomically normal |