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FLASH GENE
Symbol MSLN contributors: shn/npt - updated : 09-02-2013
HGNC name mesothelin
HGNC id 7371
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
only in ovarian carcinoma and mesotheliomas
tumoral     --over  
promotes breast cancer cell invasiveness and metastasis
tumoral     --over  
by hypomethylation in malignant mesothelioma
tumoral     --over  
in human pancreatic cancer, leading to constitutive activation of STAT3, which results in enhanced expression of cyclin E and cyclin E/cyclin-dependent kinase 2 complex formation as well as increased G(1)-S transition
Susceptibility
Variant & Polymorphism
Candidate gene
Marker useful biomarker for breast cancer progression
Therapy target
SystemTypeDisorderPubmed
cancer  
potential new therapeutic agent for preventing or treating peritoneal malignant tumors
cancerreproductivebreast
novel therapeutic or chemopreventive target in human breast cancer
ANIMAL & CELL MODELS
mice disrupted for msln gen were viable, fertile and anatomically normal