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Symbol NODAL contributors: mct - updated : 22-11-2016
HGNC name nodal homolog (mouse)
HGNC id 7865
corresponding disease(s) HTX5
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in metastatic melanomas
constitutional germinal mutation      
cause sporadic left–right (LR) patterning defects
constitutional       loss of function
reductions in the biological activity of NODAL alleles in congenital heart defects
tumoral     --over  
expression levels are significantly higher in astrocytomas, glioblastomas, oligodendrogliomas, and in malignant glioma cells compared with non-tumor tissues
tumoral     --over  
correlated with reduced patient survival in pancreatic cancer
constitutional     --low  
decreased expression of NODAL combined with haploinsufficiency for FOXA2 is the likely cause for heterotaxy, panhypopituitarism, and biliary atresia in a family (pMID: 25765999)
Susceptibility to congenital heart disease (CHD)
Variant & Polymorphism other
  • contribution to CHD of copy number changes in NODAL
  • Candidate gene
    Therapy target inhibition of Nodal signaling may be considered as a novel therapeutic strategy in glioma treatment