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FLASH GENE
Symbol PLXND1 contributors: mct/npt - updated : 28-11-2018
HGNC name plexin D1
HGNC id 9107
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in metastatic melanomas (Roodink 2008)
tumoral       gain of function
in melanoma, breast, colon, ovarian and prostate cancers
constitutional germinal mutation      
in PLXND1 and REV3L that are responsible for a proportion of Möbius syndrome (MBS) patients suggesting that de novo mutations in other genes might account for other MBS patients
constitutional germinal mutation      
in isolated truncus arteriosus
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • might be a potential cervical cancer biomarker
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    NOTCH1-PLXND1 signaling axis may be targeted to impair prostate cancer cell invasiveness and metastasis
    ANIMAL & CELL MODELS
  • PlxnD1(-/-) mice exhibited defective germinal center (GC) reactions during T-dependent immune activation