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FLASH GENE
Symbol CDC37 contributors: shn/npt - updated : 17-07-2012
HGNC name CDC37 cell division cycle 37 homolog (S. cerevisiae)
HGNC id 1735
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
loss of CDC37 function induces irreversible growth arrest in androgen receptor-positive and -negative prostate carcinoma cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
therapeutic potential of targeting CDC37 in cancer
cancerreproductiveprostate
essential for maintaining prostate tumor cell growth and may represent a novel target in the search for multitargeted therapies based on the HSP90 chaperone system
neurologyneurodegenerativealzheimer
new therapeutic targets that could be used to effectively treat neurologic devastating diseases (Alzheimer disease)
ANIMAL & CELL MODELS