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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CD163

contributors: mct - updated : 26-01-2016

HGNC name	CD163 molecule
HGNC id	1631

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in acute liver failure significantly correlated with fatal outcome and might be used with other parameters to determine prognosis constitutional     --over   during the hemorrhagic fever with renal syndrome acute phase were significantly higher in patients than during the convalescent stage and the levels in the healthy controls constitutional     --over   in monocytes of active Crohn disease (CD) or ulcerative colitis (UC), associated with increased macrophage activation constitutional     --over   in people with diabetic polyneuropathy, suggesting that inflammation plays a role in the development of neural impairment constitutional     --over   in gestational diabetes mellitus tumoral     --over   associated with poor prognosis in patients with ovarian cancer constitutional     --over   association of elevated sCD163 with organ dysfunction and adverse outcome of critical illness constitutional     --over   in patients with scleroderma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	soluble CD163 may be a potential biomarker for the severity of diabetic polyneuropathy
	soluble CD163 values were significantly higher in bone marrow samples than in the matched blood samples, and is a a novel biomarker in multiple myeloma
	may have a role as a biomarker of rheumatoid arthritis (RA) activity suggesting that resident macrophages are important for joint destruction
Therapy target

ANIMAL & CELL MODELS